CO—100 | Apply now to make the list!— APPLICATIONS OPEN
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CO—100 2026: America's Top 100 Small Businesses

Applications are open for this year's CO—100 awards program. Enter your business today for a chance to earn a spot on the list!

Small Business bAIsics: AI Training for Business Growth

Our virtual and in-person AI training, developed with support from Google and in partnership with the U.S. Chamber of Commerce Foundation, is the gateway to understanding and applying artificial intelligence in practical, powerful ways at your business.

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Interested in a small business membership?

Find out how the U.S. Chamber of Commerce can help your company grow and thrive in today's rapidly-evolving business environment. Connect with our team to learn how a small business membership can benefit your bottom line and help you achieve your goals.



Working Late? You’re Not Alone

You’re short on time and busy putting out fires. Sign up for our newsletter, Midnight Oil, and find out what you need to know to adapt and thrive tomorrow.

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Best Practices for Streamlining Payment Processing

Learn how accounts receivable automation and customer experience enhancements can improve your cash flow and bottom line.

How to Accept SMS Payments

Ready to get paid faster? Learn how to deploy a straightforward text-to-pay solution that can improve your cash flow by reducing late payments and administrative work.

AI Tools for Content Creation

These artificial intelligence-powered tools can help small businesses tackle blog and social media writing, graphic design, and audio/video content.

Businesses That Will Be in Demand in 2025 and Beyond

These five market segments are predicted to grow rapidly between 2023 and 2030.

Small Businesses Fueling the Barbecue Boom

From backyard grills to industrial-grade smoker ovens, these five small businesses are bringing the heat to meet demand for this increasingly popular product and pastime.

10 Reasons to Apply for the CO—100

The CO—100 is the U.S. Chamber of Commerce’s expanded small business awards program. Read on to find out more about the program and how to apply.

How to Spark Entrepreneurial Creativity

These five strategies can help you break out of your creative rut and spark entrepreneurial thinking.

What It Takes to Develop and Launch a Sustainable Product

The founders of PlantSwitch, Matter, and Repurpose, which make compostable dinnerware, storage containers, and more, share their strategies for landing funding, scaling production, and breaking into big retail.

Guide to Purchasing Electronic Medical Records Software

Ready to choose and buy an EMR system for your office? Learn how to find the right health care solution.

Small Business Subscription Box Services

Big companies like HelloFresh and BarkBox may seem like the only options for subscription boxes, but many small businesses are capitalizing on this consumer convenience.