CO—100 | Apply now to make the list!— APPLICATIONS OPEN
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CO—100 2026: America's Top 100 Small Businesses

Applications are open for this year's CO—100 awards program. Enter your business today for a chance to earn a spot on the list!

Small Business bAIsics: AI Training for Business Growth

Our virtual and in-person AI training, developed with support from Google and in partnership with the U.S. Chamber of Commerce Foundation, is the gateway to understanding and applying artificial intelligence in practical, powerful ways at your business.

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Interested in a small business membership?

Find out how the U.S. Chamber of Commerce can help your company grow and thrive in today's rapidly-evolving business environment. Connect with our team to learn how a small business membership can benefit your bottom line and help you achieve your goals.



Working Late? You’re Not Alone

You’re short on time and busy putting out fires. Sign up for our newsletter, Midnight Oil, and find out what you need to know to adapt and thrive tomorrow.

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Latest—

The Opportunities (and Challenges) Weight-Loss Drugs Hold for Brands Selling Everything From Food and Fitness to Fashion

Brands from Noom to Nestlé lean into shifting consumer habits with rollouts like curated fitness programs and smaller-sized meals, as peoples’ use of GLP-1 weight loss drugs takes off.

Defining Roles and Responsibilities in a Family Business

It takes many different roles and responsibilities to run a successful business. Learn how to define these roles in your organization.

RUN » BUSINESS FINANCING

How to Apply for a Business Grant

Funding your startup can be a challenge. Applying for a grant can take time but may give you that boost you need to launch or sustain your business.

RUN » HUMAN RESOURCES

How to Create an Internal Communications Strategy

Many businesses forego an internal communications strategy, which can result in a poor company culture. Find out why you need an internal communications plan and learn how to implement it.

RUN » BUSINESS FINANCING

How to Get Funding for Your Inventions

Are you ready to get paid for invention ideas or bring your design to market? Explore key considerations and seven financing methods.

U.S. Chamber of Commerce Unveils the 2025 CO—100: America’s Top 100 Small Businesses

On September 3, 2025, the U.S. Chamber of Commerce and CO— announced the CO—100, a list celebrating the top 100 small businesses in America.

START » STRATEGY

How to Structure a Family Business

Choosing the right ownership structure and governance system can protect the longevity of your company.

RUN » HUMAN RESOURCES

How to Determine Employee Pay

The job requirements and an employee's background and experience determine the salary you pay them.

Celebrities Who Are Also Entrepreneurs

Household names like Bryan Cranston, Kevin Hart, and Jennifer Garner have added "entrepreneur" to their extensive résumés.

How to Plan Ahead for the Holiday Shopping Season

Early preparation for the holiday shopping season helps small businesses boost sales, overcome challenges, and stay competitive during the most critical sales period of the year.